The importance of these documents' standards and resolutions is that the physician is bound by common bioethical duties when caring for patients during international humanitarian medical missions. The expectation for observing the fundamental bioethical principles of autonomy, beneficence, nonmaleficence, and justice remains inexplicably joined to expressions of the professional virtues of integrity, truthfulness, compassion, and trust. However, caring for patients in the unique settings of international STMMs will often pose exceptional challenges to adhere to these expectations. Understanding these challenges, based on the special socioeconomic, cultural, language, and medical milieu of a particular country, will better prepare the altruistic physician for the ethical conduct of an STMM. The issue of informed consent in humanitarian efforts is one such consideration.