Many advances in wound healing have relevance to facial plastic surgery. We briefly highlight some of these advances, including new biological and synthetic products and other potential technologies to improve wound healing, as well as the literature describing them.
Figure 1. Closure by secondary intention of full-thickness, 4-mm-diameter skin punch wounds in healthy volunteers over time. A, Control side. B, Side treated with autologous platelet-rich gel. Copyright release pending. This image was first published in the Archives as part of a single-blinded pilot study by Hom et al.26
Figure 2. An 80-year-old man with insulin-dependent diabetes mellitus, collagen vascular disease, and renal disease. A, Patient was undergoing immunosuppressive therapy and presented with a nonhealing, nonmalignant scalp wound of 1 year's duration despite treatment with standard moisture-retentive dressings. Owing to concerns of poor healing at the donor site, a split-thickness skin graft was not used, and tissue-engineered skin (Apligraf; Organogenesis) was placed in clinic. B, Apligraf before application. C, Apligraf applied to scalp wound. D, One month after Apligraf application to the scalp. E, Eight months after Apligraf application to the scalp.
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The Rational Clinical Examination
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