Accepted for Publication: November 26, 2014.
Published Online: February 26, 2015. doi:10.1001/jamafacial.2014.1574.
Study concept and design: Valente, Steffen, Carvalho, Borille, Zanella.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Valente, Steffen, Carvalho, Borille, Zanella.
Critical revision of the manuscript for important intellectual content: Valente, Steffen, Carvalho, Zanella, Padoin.
Statistical analysis: All authors.
Administrative, technical, or material support: Steffen, Carvalho, Borille, Zanella, Padoin.
Study supervision: Valente.
Conflict of Interest Disclosures: None reported.
Additional Contributions: This randomized, double-blind, placebo-controlled clinical trial was conducted at Santa Casa Hospital, Porto Alegre, Brazil.