Thirteen female patients with a mean age of 59 years (age range, 47-71 years) were entered into the study, with 6 electing to undergo HBO therapy. Eleven patients underwent a deep plane face-lift, and 2 patients, 1 each in the control group and the treatment group, underwent an extended superficial musculoaponeurotic system face-lift. There were no surgical or medical complications. One patient in the control arm missed a single postoperative appointment on POD 5, with that value unavailable for analysis. Overall, 102 photographs and 1020 data points were analyzed. On POD 1, the average degree of color change in the cheek soft-tissue flap in the HBO group was 38.5 and in the control group was 43.7. This difference was not statistically significant (P = .28). The degree of color change in the HBO group on POD 5 was 39.0 and in the control group was 45.6. Again, this difference was not statistically significant (P = .13). On POD 7, the average degree of color change in the treatment group was 27.5 and in the control group was 42.2 (P = .005), with a 35% reduction in color change in the treatment group over the control group. The average degree of color change on POD 10 was 22.0 in the treatment group and 31.6 in the control group (P = .03), with an average of 30% reduction in color change in the treatment group when compared with the control group. Figure 2 outlines the comparison between the patients undergoing HBO and the control patients.