There has been an alarming increase in methicillin-resistant Staphylococcus aureus (MRSA) infections. Richard A. Zoumalan, MD, and David B. Rosenberg, MD, retrospectively reviewed the cases of 780 patients who had undergone deep-plane rhytidectomy. They identified 5 patients (0.64%) as having postoperative site infections, and 4 patients (0.51%) as having culture findings that were positive for MRSA; 2 (0.26%) required incision and drainage, hospitalization, and intravenous antibiotics. The authors give a detailed discussion of management for each of the 5 cases and discuss screening, prevention, postoperative surveillance, and treatment of the infections. They conclude that MRSA-positive infections may become more prevalent and will require enhanced screening, prevention, and treatment strategies.