Surgical reconstruction of osseous defects remains a challenge, and the current armamentarium of treatment modalities comes with important inherent drawbacks. Controlled pharmacological osteoinduction could provide for less invasive, more anatomic, and more physiologic methods of repair. Oneida A.Arosarena, MD, and David Puleo, PhD, present results from a pluripotent murine mesenchymal cell study. The effects of separate and sequential administration of bone morphogenetic protein (BMP) 2 and 7 were quantified. Assays of extracellular matrix formation, alkaline phosphatase activity, and expression of osseous markers served as outcome measures. The authors document the variable effects of separate vs sequential administration of BMP-2 and BMP-7 and discuss implications for further research.